The Science

Our most well-respected scientific research validates the time-honored understanding that by far and away the most powerful factors affecting health and longevity are modifiable choices including the foods we eat and other aspects of lifestyle. So let’s move forward and explore this empowering information.

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Publications

Neurology Nature JAMA Cell Science Pediatrics American Journal of Clinical Nutrition BMJ The Lancet New England Journal of Medicine All Publications

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Celiac disease, brain atrophy, and dementia

American Academy of Neurology • March 14, 1991

The Contribution of Dental Amalgam to Mercury in Blood

Journal of Dental Research • May 1, 1989

The hippocampus is one of the most affected areas in Alzheimer’s disease (AD)1. Moreover, this structure hosts one of the most unique phenomena of the adult mammalian brain, namely, the addition of new neurons throughout life2. This process, called adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to the entire hip- pocampal circuitry3,4. Nonetheless, direct evidence of AHN in humans has remained elusive. Thus, determining whether new neurons are continuously incorporated into the human dentate gyrus (DG) during physiological and pathologi- cal aging is a crucial question with outstanding therapeutic potential. By combining human brain samples obtained under tightly controlled conditions and state-of-the-art tissue pro- cessing methods, we identified thousands of immature neu- rons in the DG of neurologically healthy human subjects up to the ninth decade of life. These neurons exhibited variable degrees of maturation along differentiation stages of AHN. In sharp contrast, the number and maturation of these neurons progressively declined as AD advanced. These results dem- onstrate the persistence of AHN during both physiological and pathological aging in humans and provide evidence for impaired neurogenesis as a potentially relevant mechanism underlying memory deficits in AD that might be amenable to novel therapeutic strategies

Anticholinergic drugs and risk of dementia: case-control study

British Medical Journal •

The association between obesity and lower working memory is mediated by inflammation: Findings from a nationally representative dataset of U.S. adults

Celiac Disease Facts and Figures

The University of Chicago Celiac Disease Center •

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Gut Microbiota Depletion from Early Adolescence in Mice: Implications for Brain and Behaviour

Brain, Behavior and Immunity •

Vitamin E, Memantine, and Alzheimer Disease

Journal of the American Medical Association • January 1, 0014

Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry

Journal of Physiological Anthropology • January 15, 0014

Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host–microbe interactions contributing to obesity

Obesity Reviews • September 13, 0012

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