Science

Shunsuke Murata, Marcus Ebeling, Anna C. Meyer, Katharina Schmidt-Mende, Niklas Hammar, Karin Modig

Comparing biomarker profiles measured at similar ages, but earlier in life, among exceptionally long-lived individuals and their shorter-lived peers can improve our understanding of aging processes. This study aimed to (i) describe and compare biomarker profiles at similar ages between 64 and 99 among individuals eventually becoming centenarians and their shorter-lived peers, (ii) investigate the association between specific biomarker values and the chance of reaching age 100, and (iii) examine to what extent cen- tenarians have homogenous biomarker profiles earlier in life. Participants in the population-based AMORIS cohort with information on blood-based biomarkers measured during 1985–1996 were followed in Swed- ish register data for up to 35 years. We examined bio- markers of metabolism, inflammation, liver, renal, anemia, and nutritional status using descriptive statistics,logistic regression, and cluster analysis. In total, 1224 participants (84.6% females) lived to their 100th birth- day. Higher levels of total cholesterol and iron and lower levels of glucose, creatinine, uric acid, aspar- tate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, and total iron-binding capacity were associated with reaching 100 years. Centenarians overall displayed rather homogenous biomarker profiles. Already from age 65 and onwards, centenarians displayed more favorable biomarker values in commonly available biomarkers than individuals dying before age 100. The differences in biomarker values between centenarians and non- centenarians more than one decade prior death suggest that genetic and/or possibly modifiable lifestyle factors reflected in these biomarker levels may play an important role for exceptional longevity.