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Brain Defenders confronts a stark reality: we have no meaningful treatment for devastating neurodegenerative conditions like Alzheimer’s and Parkinson’s. Current medical approaches focus almost entirely on symptom management, offering temporary relief while leaving the underlying disease processes untouched. It is the equivalent of treating smoke while ignoring the fire.
At the heart of this book lies a revolutionary shift in understanding brain health: the pivotal role of microglia, the brain’s immune cells. These tiny sentinels are both protectors and potential destroyers. When functioning properly, they preserve brain resilience, repair damage, and nurture connections. But under the wrong conditions, they can ignite inflammation and accelerate degeneration, often well before hallmark changes like beta-amyloid appear.
Through the emerging science of immunometabolism, we now know that microglia are governed by their metabolic state. When metabolism is balanced, microglia remain supportive (M2). When disrupted, they turn destructive (M1). Because microglial metabolism mirrors our own systemic metabolism, our daily lifestyle choices directly determine their fate.
Brain Defenders provides readers with both the science and a detailed action plan. It identifies the threats, including poor diet, environmental toxins, polluted air, lack of restorative sleep, and shows how to counter them with practical, evidence-based strategies. It also explores cutting-edge research and technologies that target microglial function to protect and restore brain health.
This book is about empowerment: enabling each reader to become the architect of their brain’s future.
Written by neurologist David Perlmutter, MD, six-time New York Times bestselling author and Fellow of The American College of Nutrition, Brain Defenders charts a path toward vibrant cognitive longevity.
In addition to America, Brain Defenders will be published in Canada, France, Germany, Spain, Italy, Romania, United Kingdom, South Korea, Brazil, China (Simplified).