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In Brain Defenders, 6-time New York Times bestselling author, David Perlmutter, MD, introduces a revolutionary understanding of neurodegenerative diseases, shifting focus from dying neurons to the brain’s immune cells— the microglia. These cells, profoundly influenced by metabolism, can either protect the brain (M2 state) or promote destruction (M1 state). This insight transforms our understanding of conditions like Alzheimer’s, Parkinson’s, depression, and even long COVID. The metabolic health of microglia—not genetics alone— determines our cognitive fate. With lifestyle changes, cutting-edge therapies, and metabolic interventions, we can now aggressively influence this cellular battleground, offering not just symptom relief but real potential for prevention and improvement. Dr. Perlmutter leverages the leading edge of neuroscientific research, allowing the reader to be the architect of their brain’s destiny.