The Science

Our most well-respected scientific research validates the time-honored understanding that by far and away the most powerful factors affecting health and longevity are modifiable choices including the foods we eat and other aspects of lifestyle. So let’s move forward and explore this empowering information.

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The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adults

Clinical Nutrition • November 1, 2022

Precision Medicine Approach to Alzheimer’s Disease: Successful Proof-of-Concept Trial

Preprint • May 11, 2021

Serum uric acid and cognitive function in community-dwelling older adults

Neuropsychology • August 29, 2006

Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline

JAMA Network Open • January 15, 2021

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

The American Journal of Clinical Nutrition • December 30, 2015

Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years

Current Biology • September 3, 2020

Association Between Sleep Duration and Cognitive Decline

JAMA Network Open • September 21, 2020

The impact of exposure to air pollution on cognitive performance

Proceedings of the National Academy of Sciences • July 23, 2018

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

Scientific Reports • September 21, 2018

Reversal of Cognitive Decline: 100 Patients

Journal of Alzheimer’s Disease & Parkinsonism • October 19, 2018

HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing

Diabetologia • December 8, 2017

Midlife hypertension and 20-year cognitive change: The Atherosclerosis Risk in Communities Neurocognitive Study

Neurology • October 1, 2014

EGCG ameliorates high-fat– and high-fructose–induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

FASEB Journal • November 30, 2017

APOE effects on cognition from childhood to adolescence

Neurobiology of Aging • April 14, 2019

A chronic low dose of ∆9-tetrahydrocannabinol (THC) restores cognitive function in old mice

Nature Medicine • May 8, 2017

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